A cis-encoded sRNA controls the expression of fabH2 in Yersinia |
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| Authors: | Pei Lu Yong Zhang Yangbo Hu Matthew S Francis Shiyun Chen |
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| Institution: | 1. Key Laboratory of Etiology and Biosafety for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China;2. Department of Molecular Biology and Umeå Centre for Microbial Research (UCMR), Umeå University, SE-901 87 Umeå, Sweden |
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| Abstract: | YsrH is a novel cis-encoded sRNA located on the opposite strand to fabH2, which is essential for fatty acid biosynthesis in bacteria. In this study, YsrH-mediated regulation of fabH2 expression was investigated in Yersinia pseudotuberculosis. Constitutive and inducible over-expression of YsrH decreased the mRNA level of fabH2, while expression of downstream fabD and fabG remained unaffected. Polynucleotide phosphorylase (PNPase) also played an important role in this regulation process by mediating YsrH decay in the exponential phase. Thus, our data defines a cis-encoded sRNA that regulates fatty acid synthesis via a regulatory mechanism also involving PNPase. |
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| Keywords: | 3-oxoacyl-ACP synthase (fabH2) Yersinia sRNA regulator of fabH2 (YsrH) cis-Encoded sRNA PNPase Yersinia |
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