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RBM10 regulates alternative splicing
Authors:Akira Inoue  Naoki Yamamoto  Masatsugu Kimura  Koji Nishio  Hideo Yamane  Koichi Nakajima
Institution:1. Department of Immunology, Osaka City University Graduate School of Medicine, Japan;2. Department of Otolaryngology, Osaka City University Graduate School of Medicine, Japan;3. Department of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental University Graduate School, Japan;4. Department of Radioisotope Center, Osaka City University Graduate School of Medicine, Japan;5. Department of Anatomy and Cell Biology, Graduate School of Medicine, Nagoya University, Japan
Abstract:RBM10, originally called S1-1, is a nuclear RNA-binding protein with domains characteristic of RNA processing proteins. It has been reported that RBM10 constitutes spliceosome complexes and that RBM5, a close homologue of RBM10, regulates alternative splicing of apoptosis-related genes, Fas and cFLIP. In this study, we examined whether RBM10 has a regulatory function in splicing similar to RBM5, and determined that it indeed regulates alternative splicing of Fas and Bcl-x genes. RBM10 promotes exon skipping of Fas pre-mRNA as well as selection of an internal 5′-splice site in Bcl-x pre-mRNA. We propose a consensus RBM10-binding sequence at 5′-splice sites of target exons and a mechanistic model of RBM10 action in the alternative splicing.
Keywords:S1-1  RBM10  RBM5  Alternative splicing  Fas  Bcl-x
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