End-binding protein 1 (EB1) up-regulation is an early event in colorectal carcinogenesis |
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Authors: | Yolanda Stypula-Cyrus Nikhil N. Mutyal Mart Dela Cruz Dhananjay P. Kunte Andrew J. Radosevich Ramesh Wali Hemant K. Roy Vadim Backman |
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Affiliation: | 1. Biomedical Engineering Department, Northwestern University, Evanston, IL 60208, USA;2. Department of Medicine, Boston Medical Center, Boston, MA 02118, USA;3. Department of Internal Medicine, NorthShore University Health System, Evanston, IL 60201, USA |
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Abstract: | End-binding protein (EB1) is a microtubule protein that binds to the tumor suppressor adenomatous polyposis coli (APC). While EB1 is implicated as a potential oncogene, its role in cancer progression is unknown. Therefore, we analyzed EB1/APC expression at the earliest stages of colorectal carcinogenesis and in the uninvolved mucosa (“field effect”) of human and animal tissue. We also performed siRNA-knockdown in colon cancer cell lines. EB1 is up-regulated in early and field carcinogenesis in the colon, and the cellular/nano-architectural effect of EB1 knockdown depended on the genetic context. Thus, dysregulation of EB1 is an important early event in colon carcinogenesis. |
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Keywords: | End-binding protein 1 Adenomatous polyposis coli Colon cancer Field carcinogenesis Sub-diffractional structure |
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