Src regulates membrane trafficking of the Kv3.1b channel |
| |
Authors: | Seong Han Bae Dong Hyun Kim Seok Kyo Shin Jin Sung Choi Kang-Sik Park |
| |
Affiliation: | 1. Department of Physiology, Kyung Hee University School of Medicine, Seoul 130-701, South Korea;2. Biomedical Science Institute, Kyung Hee University School of Medicine, Seoul 130-701, South Korea;3. College of Pharmacy, Catholic University of Korea, Bucheon 420-743, Gyeonggi-Do, South Korea |
| |
Abstract: | The Kv3.1 channel plays a crucial role in regulating the high-frequency firing properties of neurons. Here, we determined whether Src regulates the subcellular distributions of the Kv3.1b channel. Co-expression of active Src induced a dramatic redistribution of Kv3.1b to the endoplasmic reticulum. Furthermore, co-expression of the Kv3.1b channel with active Src induced a remarkable decrease in the pool of Kv3.1b at the cell surface. Moreover, the co-expression of active Src results in a significant decrease in the peak current densities of the Kv3.1b channel, and a substantial alteration in the voltage dependence of its steady-state inactivation. Taken together, these results indicate that Src kinase may play an important role in regulating membrane trafficking of Kv3.1b channels. |
| |
Keywords: | Potassium channel Kv3.1b Src Membrane trafficking |
本文献已被 ScienceDirect 等数据库收录! |
|