MiR-152 reduces human umbilical vein endothelial cell proliferation and migration by targeting ADAM17 |
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Authors: | Yang Wu Aixue Huang Tao Li Xueting Su Hongmei Ding Hui Li Xingliang Qin Lubin Hou Qiang Zhao Xingfeng Ge Tao Fang Rong Wang Changqing Gao Jie Li Ningsheng Shao |
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Institution: | 1. General Hospital of Chinese People’s Liberation Army, Beijing 100853, PR China;2. Beijing Institute of Basic Medical Sciences, Beijing 100850, PR China;3. Affiliated Hospital of General Hospital of Chinese People’s Liberation Army, Beijing 100048, PR China |
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Abstract: | As a cleavage enzyme of precursor TNF-α, the high expression level of ADAM17 in endothelial cells is an important factor in atherosclerosis. In this study, we demonstrate that ADAM17 is the target of miR-152. We found that miR-152 could reduce TNF precursor cleavage and inhibit cell proliferation and migration by targeting ADAM17 in human umbilical vein endothelial cells (HUVECs). Furthermore, the expression pattern of miR-152 and corresponding target ADAM17 was opposite in HUVECs under hypoxic conditions. The levels of circulating miR-152 in AS patient sera were lower than those detected in the sera of normal individuals. Our results indicate that miR-152 may be involved in the development of human atherosclerosis and could be used as diagnostic biomarker or therapeutic target in atherosclerosis. |
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Keywords: | MiR-152 ADAM17 HUVEC Atherosclerosis |
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