MicroRNA-106a targets TIMP2 to regulate invasion and metastasis of gastric cancer |
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| Authors: | Meng Zhu Ning Zhang Shuixiang He Yuanyuan Lui Guifang Lu Lin Zhao |
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| Affiliation: | 1. Department of Gastroenterology, First Affiliated Hospital of Xi’an Jiaotong University, 277 West Yanta Rood, Xi’an, Shanxi 710061, People’s Republic of China;2. Department of Pathology, General Hospital of Ningxia Medical University, Yinchuan, People’s Republic of China;3. Department of Gastroenterology, The Central Hospital of Xi’an, Xi’an, People’s Republic of China |
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| Abstract: | Emerging evidence has shown that microRNA plays an important role in tumor development and progression. Here, we report that miR-106a is frequently up-regulated in gastric cancer tissues and positively correlates with metastasis. Restrained expression of miR-106a in gastric cancer cells significantly reduces their capacity of proliferation, migration and invasion. In tissue sections, the positive signal of miR-106a localized in metastasis-associated regions confirmed this result. Moreover, we show that TIMP2 is a direct downstream target for miR-106a and knockdown of TIMP2 strengthens the beneficial effects of miR-106a. Our study adds miR-106a to the complex mechanisms of tumor metastasis. |
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| Keywords: | FFPE Formalin-fixed paraffin-embedded |
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