Hepatitis B virus X increases immune cell recruitment by induction of chemokine SDF-1 |
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Authors: | Hyun Kook Cho So Young Kim Je Kyung Seong JaeHun Cheong |
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Institution: | 1. Department of Molecular Biology, Pusan National University, Busan 609-735, Republic of Korea;2. Laboratory of Developmental Biology and Genomics, College of Veterinary Medicine, Interdisciplinary Program for Bioinformatics, and Program for Cancer Biology, Seoul National University, Seoul, Republic of Korea |
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Abstract: | Hepatitis B virus X protein is a major factor in the HBV-induced disease developments. Stromal cell-derived factor-1 is a small cytokine that is strongly chemotactic for lymphocytes. We explored the role of HBx on recruitment of HBV-induced virus-nonspecific immune cells into liver. Immune cell recruitment and SDF-1 expression level significantly increased in livers of HBx-transgenic mice and X-box binding protein-1 significantly increased SDF-1 gene expression. Finally, we confirmed that immune cell recruitment into liver tissues of HBx-TG mice was diminished by a chemokine receptor antagonist. Therefore, HBx increases ER stress-dependent SDF-1 expression and induces HBV-induced immune cell recruitment into liver. |
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Keywords: | ER stress HBx Immune cell recruitment SDF-1 XBP1 |
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