Site-specific phosphorylation of Tau protein is associated with deacetylation of microtubules in mouse spermatogenic cells during meiosis |
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Authors: | Hiroki Inoue Yuuki Hiradate Yoshiki Shirakata Kenta Kanai Keita Kosaka Aina Gotoh Yasuhiro Fukuda Yutaka Nakai Takafumi Uchida Eimei Sato Kentaro Tanemura |
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Affiliation: | 1. Laboratory of Animal Reproduction and Development, Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amamiyamachi, Aobaku, Sendai 981-8555, Japan;2. Molecular Enzymology, Department of Molecular Cell Science, Tohoku University, 1-1 Tsutsumidori-Amamiyamachi, Aobaku, Sendai 981-8555, Japan;3. Laboratory of Sustainable Environmental Biology, Graduate School of Agricultural Science, Tohoku University, 232-3 Yomogida, Naruko-onsen, Osaki, Miyagi 989-6711, Japan;4. National Livestock Breeding, 1 Odakurahara, Odakura, Nishigo-mura, Nishishirakawa-gun, Fukushima 961-8511, Japan |
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Abstract: | Tau is one of the microtubule-associated proteins and a major component of paired helical filaments, a hallmark of Alzheimer’s disease. Its expression has also been indicated in the testis. However, its function and modification in the testis have not been established. Here, we analyzed the dynamics of phosphorylation patterns during spermatogenesis. The expression of Tau protein and its phosphorylation were shown in the mouse testis. Immunohistochemistry revealed that the phosphorylation was strongly detected during meiosis. Correspondingly, the expression of acetylated tubulin was inversely weakened during meiosis. These results suggest that phosphorylation of Tau protein contributes to spermatogenesis, especially in meiosis. |
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Keywords: | Meiosis Spermatogenesis Testis Tau |
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