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Tumour-suppressive microRNA-224 inhibits cancer cell migration and invasion via targeting oncogenic TPD52 in prostate cancer |
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| Authors: | Yusuke Goto Rika Nishikawa Satoko Kojima Takeshi Chiyomaru Hideki Enokida Satoru Inoguchi Takashi Kinoshita Miki Fuse Shinichi Sakamoto Masayuki Nakagawa Yukio Naya Tomohiko Ichikawa Naohiko Seki |
| Affiliation: | 1. Department of Functional Genomics, Chiba University Graduate School of Medicine, Chiba, Japan;2. Department of Urology, Chiba University Graduate School of Medicine, Chiba, Japan;3. Department of Urology, Teikyo University Chiba Medical Centre, Chiba, Japan;4. Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan |
| Abstract: | Our recent study of the microRNA expression signature of prostate cancer (PCa) revealed that microRNA-224 (miR-224) is significantly downregulated in PCa tissues. Here, we found that restoration of miR-224 significantly inhibits PCa cell migration and invasion. Additionally, we found that oncogenic TPD52 is a direct target of miR-224 regulation. Silencing of the TPD52 gene significantly inhibits cancer cell migration and invasion. Moreover, TPD52 expression is upregulated in cancer tissues and negatively correlates with miR-224 expression. We conclude that loss of tumour-suppressive miR-224 enhances cancer cell migration and invasion in PCa through direct regulation of oncogenic TPD52. |
| Keywords: | miR-224 TPD52 Prostate cancer microRNA Tumour suppressor |
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