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Molecular cloning,regulation, and functional analysis of two GHS-R genes in zebrafish |
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| Authors: | Ji Eom Areum Hong Young-Ho Kang Han-Ju Yoo Eun-Ju Chang Sang-Wook Kang Seung-Yong Yoon Sang-Yeob Kim Youngsup Song |
| Institution: | 1. Department of Biomedical Sciences, Cell Dysfunction Research Center (CDRC), University of Ulsan, College of Medicine, Olympic-ro 43-gil 88, SongPa-Gu, Seoul 138-736, Republic of Korea;2. Department of Anatomy and Cell Biology, University of Ulsan, College of Medicine, Seoul 138-736, Republic of Korea;3. Asan Institute for Life Sciences, Asan Medical Center, Seoul 138-736, Republic of Korea;4. Department of medicine, University of Ulsan, College of Medicine, Seoul 138-736, Republic of Korea |
| Abstract: | Mammalian ghrelin is derived from stomach and regulates growth hormone release and appetite by modulating GHS-R (Growth hormone secretagogue receptor) activity. Zebrafish has been developed as a forward genetic screening model system and previous screening identified a number of genes involved in multiple signaling pathways. In this system, ghrelin has been identified and its function and regulation have been shown to be highly conserved to that of mammals. |
| Keywords: | Ghrelin GHS-R Zebrafish Ca2+ oscillation |
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