miR-625 down-regulation promotes proliferation and invasion in esophageal cancer by targeting Sox2 |
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| Authors: | Zhiqiang Wang Qiao Qiao Min Chen Xianhua Li Zhenjun Wang Chuanxin Liu Zongtao Xie |
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| Affiliation: | 1. Department of Thoracic and Cardiovascular Surgery, Affiliated Hospital of Jiangnan University, The Forth People’s Hospital of Wuxi City, Wuxi 214062, People’s Republic of China;2. Department of Gastroenterology, Affiliated Hospital of Jiangnan University, The Forth People’s Hospital of Wuxi City, Wuxi 214062, People’s Republic of China;3. Department of Clinical Laboratory, Affiliated Hospital of Jiangnan University, The Forth People’s Hospital of Wuxi City, Wuxi 214062, People’s Republic of China |
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| Abstract: | miR-625 has been reported to exhibit abnormal expression in esophageal cancer (EC), but the mechanism and functions of miR-625 in esophageal cancer remain unclear. miR-625 down-regulation and Sox2 up-regulation were validated by qRT-PCR in 158 EC samples. Low expression of miR-625 promotes cell proliferation and invasion, while high expression of miR-625 has the opposite effect. Sox2, a target gene of miR-625, was examined by luciferase assay and western blot. Our data suggest that miR-625 may regulate the biological processes of EC via controlling Sox2 expression. |
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| Keywords: | miR-625 Sox2 Proliferation Invasion Esophageal cancer |
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