活心丸联合尼可地尔对冠心病稳定型心绞痛患者心功能、血脂和血液流变学的影响

摘要 目的：观察活心丸联合尼可地尔对冠心病稳定型心绞痛（SA）患者心功能、血脂和血液流变学的影响。方法：根据随机数字表法将我院2020年8月至2022年2月期间收治的130例冠心病SA患者分为对照组（尼可地尔治疗，n=65）和联合组（尼可地尔联合活心丸治疗，n=65）。对比两组心功能指标、临床症状改善情况、血液流变学指标、血脂指标、疗效以及不良反应。结果：对照组的总有效率低于联合组（P<0.05）。与对照组治疗3个月后相比，联合组的心绞痛发作持续时间更短，每周发作次数更少，每搏输出量（CO）、高密度脂蛋白胆固醇（HDL-C）、左心室射血分数（LVEF）更高，总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、左室舒张末期内径（LVEDD）、三酰甘油（TG）、全血粘度高切/低切、血浆粘度、纤维蛋白原更低（P<0.05）。对照组与联合组不良反应发生率对比无差异（P>0.05）。结论：采用活心丸联合尼可地尔治疗冠心病SA，可提高临床疗效，改善心功能，调节血脂和血液流变学水平。

Effects of Huoxin Pill Combined with Nicorandil on Cardiac Function, Blood Lipid and Hemorheology in Patients with Stable Angina Pectoris of Coronary Heart Disease

ABSTRACT Objective: To observe the effects of huoxin pills combined with nicorandil on cardiac function, blood lipid and hemorheology in patients with stable angina pectoris (SA) of coronary heart disease. Methods: According to the random number table method, 130 SA patients with coronary heart disease admitted to our hospital from August 2020 to February 2022 were divided into control group (nicorandil treatment, n=65) and combined group (nicorandil combine with huoxin pill treatment, n=65). The cardiac function indexes, clinical symptom improvement, hemorheology indexes, blood lipid indexes, efficacy and adverse reactions were compared between two groups. Results: The total effective rate in control group was lower than that in combined group (P<0.05). Compared with control group 3 months after treatment, the duration of angina pectoris in combined group was shorter, the number of episodes per week was less, the stroke volume (CO), high-density lipoprotein cholesterol (HDL-C), left ventricular ejection fraction (LVEF) were higher, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), left ventricular end-diastolic diameter (LVEDD), triglyceride (TG), whole blood viscosity high shear/low shear, plasma viscosity, fibrinogen were lower(P<0.05). There was no difference in the incidence of adverse reactions between the control group and the combined group(P>0.05). Conclusion: The treatment of coronary heart disease SA with huoxin pills combined with nicorandil, which can improve clinical efficacy, improve cardiac function, and regulate blood lipid and hemorheology.