Phenotypic conversion of human erythrocytes by H-Y antigen |
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Authors: | U Müller Antonia Mayerová J W Siebers U Wolf |
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Institution: | (1) Institut für Humangenetik und Anthropologie der Universität, Albertstraße 11, D-7800 Freiburg, Federal Republic of Germany;(2) Universitäts-Frauenklinik, Hugstetterstraße 55, D-7800 Freiburg, Federal Republic of Germany |
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Abstract: | Summary Human male erythrocytes absorb H-Y antiserum while those of human females do not. Studies on the mode of attachment of H-Y antigen to the erythrocyte membrane reveal: (1) After several washes H-Y antigen can only be removed from male erythrocytes and not from other male cells such as granulocytes. (2) Female erythrocytes absorb exogenous H-Y antigen and thus become H-Y positive. (3) Complement mediated lysis of erythrocytes by H-Y antiserum is not sex specific but is dependent on the AB0 blood group type of the red blood cells. It is concluded that H-Y antigen is unspecifically attached to red blood cells and is therefore not an integral part of the erythrocyte membrane.This work was supported by the Deutsche Forschungsgemeinschaft (SFB 46 and Si 185/4) |
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