Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery |
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| Authors: | Dong Yun Lee David Arnott Eric J Brown |
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| Affiliation: | 1. Department of Infectious Disease, , South San Francisco, California, 94080 USA;2. Department of Protein Chemistry, Genentech Inc., , South San Francisco, California, 94080 USA |
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| Abstract: | Ubiquilins (Ubqlns)—a family of ubiquitin‐binding proteins—are involved in several protein degradation pathways and have been implicated in various neurodegenerative diseases. Ubqln1 regulates autophagosome maturation during autophagy‐mediated degradation. We now show that Ubqln4 mediates the interaction between Ubqln1 and the autophagy machinery by recruiting Ubqln1 to LC3. This targeting of Ubqln1 to autophagosomes requires the Ubqln4 UBL domain and the Ubqln1 UBA domain. This study identifies a new role for Ubqln4, expanding the role for Ubqlns in protein degradation. |
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| Keywords: | autophagy LC3 Ubqln1 Ubqln4 |
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