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Endogenous electric currents might guide rostral migration of neuroblasts |
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| Authors: | Brian Reid Siwei Zhao Jin Pu Tingrui Pan Ebenezer N Yamoah Min Zhao |
| Institution: | 1. Department of Dermatology, University of California, Davis, 3301 C Street, , Sacramento, California, 95816 USA;2. Center for Neuroscience, University of California, Davis, 1544 Newton Court, , Davis, California, 95618 USA;3. Institute of Regenerative Cures, School of Medicine, University of California, Davis, 2315 Stockton Blvd, , Sacramento, California, 95817 USA;4. Department of Biomedical Engineering, University of California, One Shields Avenue, , Davis, California, 95616 USA;5. School of Medical Sciences, University of Aberdeen, , Aberdeen AB25 2ZD, Scotland, UK;6. Department of Anesthesiology and Pain Medicine, University of California, Davis, 4150 V Street, , Sacramento, California, 95817 USA;7. Department of Ophthalmology, University of California, Davis, , Sacramento, California, 95817 USA |
| Abstract: | Mechanisms that guide directional migration of neuroblasts from the subventricular zone (SVZ) are not well understood. We report here that endogenous electric currents serve as a guidance cue for neuroblast migration. We identify the existence of naturally occurring electric currents (1.5±0.6 μA/cm2, average field strength of ～3 mV/mm) along the rostral migration path in adult mouse brain. Electric fields of similar strength direct migration of neuroblasts from the SVZ in culture and in brain slices. The purinergic receptor P2Y1 mediates this migration. The results indicate that naturally occurring electric currents serve as a new guidance mechanism for rostral neuronal migration. |
| Keywords: | neuroblast rostral migration electric field electrical corridors purinergic receptor |