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PP2A regulatory subunit Bα controls endothelial contractility and vessel lumen integrity via regulation of HDAC7
Authors:Maud Martin  Ilse Geudens  Jonathan Bruyr  Michael Potente  Anouk Bleuart  Marielle Lebrun  Nicolas Simonis  Christophe Deroanne  Jean‐Claude Twizere  Philippe Soubeyran  Paul Peixoto  Denis Mottet  Veerle Janssens  Wolf‐Karsten Hofmann  Filip Claes  Peter Carmeliet  Richard Kettmann  Holger Gerhardt  Franck Dequiedt
Institution:1. Laboratory of Protein Signaling and Interactions, Interdisciplinary Cluster for Applied Genoproteomics (GIGA‐R), University of Liège, , Sart‐Tilman, Belgium;2. Vascular Patterning Laboratory, VRC, VIB, , Leuven, Belgium;3. Department of Oncology, Vascular Patterning Laboratory, VRC, KU Leuven, , Leuven, Belgium;4. Max‐Planck‐Institute for Heart and Lung Research, Angiogenesis and Metabolism Laboratory, , Bad Nauheim, Germany;5. Department of Cardiology, Internal Medicine III, Goethe University, , Frankfurt, Germany;6. Laboratory of Virology and Immunology, GIGA‐R, University of Liège, , Sart‐Tilman, Belgium;7. Laboratoire de Bioinformatique des Génomes et des Réseaux (BiGRe), Université Libre de Bruxelles (ULB), , Bruxelles, Belgium;8. Laboratory of Connective Tissues Biology, GIGA‐Cancer, University of Liège, , Sart‐Tilman, Belgium;9. CRCM, INSERM U1068;10. Institut Paoli‐Calmettes;11. Aix‐Marseille Université, UM105;12. CNRS, UMR7258, , Marseille, France;13. Metastasis Research Laboratory, GIGA‐Cancer, University of Liege, , Liege, Belgium;14. Laboratory of Protein Phosphorylation and Proteomics, Department of Cellular and Molecular Medicine, Faculty of Medicine, KU Leuven, , Leuven, Belgium;15. Department of Hematology and Oncology, University Hospital, , Mannheim, Germany;16. Research Group Neural Circuit Development and Regeneration, Department of Biology, Katholieke Universiteit Leuven (KU Leuven), , Leuven, Belgium;17. Laboratory of Angiogenesis and Neurovascular Link, VRC, VIB, , Leuven, Belgium;18. Laboratory of Angiogenesis and Neurovascular Link, Department of Oncology, KU Leuven, , Leuven, Belgium;19. Vascular Biology Laboratory, London Research Institute—Cancer Research UK, , London, UK
Abstract:
Keywords:angiogenesis  cytoskeleton  HDAC  lumen maintenance  phosphatase
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