Factors affecting treatment outcome in patients with idiopathic nonspecific interstitial pneumonia: a nationwide cohort study |
| |
Authors: | Sang Hoon Lee Moo Suk Park Song Yee Kim Dong Soon Kim Young Whan Kim Man Pyo Chung Soo Taek Uh Choon Sik Park Sung Woo Park Sung Hwan Jeong Yong Bum Park Hong Lyeol Lee Jong Wook Shin Eun Joo Lee Jin Hwa Lee Yangin Jegal Hyun Kyung Lee Yong Hyun Kim Jin Woo Song Jong Sun Park |
| |
Affiliation: | 1.Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine,Seoul National University Bundang Hospital,Seongnam-si,Republic of Korea;2.Yonsei University College of Medicine,Seoul,South Korea;3.Department of Internal Medicine, Division of Pulmonology, Severance Hospital, Institute of Chest Diseases,Yonsei University College of Medicine,Seoul,South Korea;4.Division of Pulmonary and Critical Care Medicine,University of Ulsan College of Medicine, Asan Medical Center,Seoul,South Korea;5.Department of Internal Medicine and Lung Institute, Division of Pulmonary and Critical Care Medicine,Seoul National University College of Medicine,Seoul,South Korea;6.Division of Pulmonary and Critical Care Medicine, Samsung Medical Center,Sungkyunkwan University School of Medicine,Seoul,South Korea;7.Department of Internal Medicine, Division of Allergy and Respiratory Medicine,Soonchunhyang University Seoul Hospital,Seoul,South Korea;8.Department of Internal Medicine, Division of Allergy and Respiratory Medicine,Soonchunhyang University Bucheon Hospital,Bucheon,South Korea;9.Department of Internal Medicine, Division of Pulmonology,Gachon University Gil Medical Center,Incheon,South Korea;10.Department of Internal Medicine, Division of Pulmonary, Allergy & Critical Care Medicine, Kangdong Sacred Heart Hospital,Hallym University,Seoul,South Korea;11.Department of Internal Medicine, Pulmonary Division,Inha University Hospital,Incheon,South Korea;12.Department of Internal medicine, Division of Pulmonary Medicine,Chung Ang University College of Medicine,Seoul,South Korea;13.Department of Internal Medicine, Division of Respiratory and Critical Care Medicine, Korea University Anam Hospital,Korea University College of Medicine,Seoul,South Korea;14.Department of Internal Medicine, Ewha Medical Research Institute,Ewha Womans University School of Medicine,Seoul,South Korea;15.Department of Internal Medicine, Division of Pulmonary Medicine, Ulsan University Hospital,University of Ulsan College of Medicine,Ulsan,South Korea;16.Department of Internal Medicine, Division of Critical Care and Pulmonary Medicine,Inje University Busan Paik Hospital,Busan,South Korea;17.Department of Internal Medicine, Division of Allergy and Pulmonology, Bucheon St. Mary’s Hospital,The Catholic University of Korea School of Medicine,Bucheon,South Korea |
| |
Abstract: | BackgroundThe effects of corticosteroid-based therapy in patients with idiopathic nonspecific interstitial pneumonia (iNSIP), and factors affecting treatment outcome, are not fully understood. We aimed to investigate the long-term treatment response and factors affecting the treatment outcome in iNSIP patients from a multi-center study in Korea.MethodsThe Korean interstitial lung disease (ILD) Study Group surveyed ILD patients from 2003 to 2007. Patients were divided into two groups to compare the treatment response: response group (forced vital capacity (FVC) improves ≥10% after 1 year) and non-response group (FVC <10%). Factors affecting treatment response were evaluated by multivariate logistic regression analysis.ResultsA total of 261 patients with iNSIP were enrolled, and 95 patients were followed-up for more than 1 year. Corticosteroid treatment was performed in 86 patients. The treatment group showed a significant improvement in lung function after 1-year: FVC, 10.0%; forced expiratory volume (FEV1), 9.8%; diffusing capacity of the lung for carbon monoxide (DLco), 8.4% (p?0.001). Sero-negative anti-nuclear antibody (ANA) was significantly related with lung function improvement. Sero-positivity ANA was significantly lower in the response group (p?=?0.013), compared to that in the non-response group. A shorter duration of respiratory symptoms at diagnosis was significantly associated with a good response to treatment (p?=?0.018).ConclusionTreatment with corticosteroids and/or immunosuppressants improved lung function in iNSIP patients, which was more pronounced in sero-negative ANA and shorter symptom duration patients. These findings suggest that early treatment should be considered in iNSIP patients, even in an early disease stage. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|