Expression analysis of Foxp3 in T cells from bovine leukemia virus infected cattle |
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| Authors: | Tomohiro Okagawa Ryoyo Ikebuchi Tatsuya Shirai Yuji Sunden Claro N Mingala Shiro Murata Kazuhiko Ohashi |
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| Institution: | 1. Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, , Sapporo, 060‐0818 Japan;2. Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, , Sapporo, 060‐0818 Japan;3. Philippine Carabao Center National Headquarters and Gene Pool, Science City of Munoz, , 3120 Nueva Ecija, Philippines |
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| Abstract: | In the present study, we monitored Foxp3+ T cells in bovine leukemia virus (BLV)‐infected cattle. By flow cytometric analysis, the proportion of Foxp3+CD4+ cells from persistent lymphocytotic cattle was significantly increased compared to control and AL cattle. Interestingly, the proportion of Foxp3+CD4+ cells correlated positively with the increased number of lymphocytes, virus titer and virus load, whereas it inversely correlated with IFN‐γ mRNA expression, suggesting that Foxp3+CD4+ T cells in cattle have a potentially immunosuppressive function. Further studies are necessary to elucidate the detailed mechanism behind the increased Treg during BLV infection. |
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| Keywords: | bovine leukemia virus (BLV) CD4 Foxp3 |
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