Towards a consensus on datasets and evaluation metrics for developing B-cell epitope prediction tools |
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Authors: | Greenbaum Jason A Andersen Pernille Haste Blythe Martin Bui Huynh-Hoa Cachau Raul E Crowe James Davies Matthew Kolaskar A S Lund Ole Morrison Sherrie Mumey Brendan Ofran Yanay Pellequer Jean-Luc Pinilla Clemencia Ponomarenko Julia V Raghava G P S van Regenmortel Marc H V Roggen Erwin L Sette Alessandro Schlessinger Avner Sollner Johannes Zand Martin Peters Bjoern |
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Institution: | Immune Epitope Database and Analysis Resource (IEDB), La Jolla Institute for Allergy and Immunology, La Jolla, California, USA. jgbaum@liai.org |
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Abstract: | A B-cell epitope is the three-dimensional structure within an antigen that can be bound to the variable region of an antibody. The prediction of B-cell epitopes is highly desirable for various immunological applications, but has presented a set of unique challenges to the bioinformatics and immunology communities. Improving the accuracy of B-cell epitope prediction methods depends on a community consensus on the data and metrics utilized to develop and evaluate such tools. A workshop, sponsored by the National Institute of Allergy and Infectious Disease (NIAID), was recently held in Washington, DC to discuss the current state of the B-cell epitope prediction field. Many of the currently available tools were surveyed and a set of recommendations was devised to facilitate improvements in the currently existing tools and to expedite future tool development. An underlying theme of the recommendations put forth by the panel is increased collaboration among research groups. By developing common datasets, standardized data formats, and the means with which to consolidate information, we hope to greatly enhance the development of B-cell epitope prediction tools. |
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Keywords: | B‐cell epitopes epitope prediction algorithms immunology databases data standardization bioinformatics software tools tool development |
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