The stereospecificity of the ferrous-ion-dependent alcohol dehydrogenase from Zymomonas mobilis |
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| Authors: | A Glasfeld S A Benner |
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| Affiliation: | Laboratorium für Organische Chemie, Eidgen?ssische Technische Hochschule, Zürich, Switzerland. |
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| Abstract: | Alcohol dehydrogenase from Zymomonas mobilis has been found to transfer the pro-R hydrogen of NADH to acetaldehyde. This is the first report of the stereospecificity of a dehydrogenase in the mechanistic and structural class of Fe2+-dependent alcohol dehydrogenases and offers an opportunity to expand mechanistic hypotheses relating stereospecificity, reaction mechanism and reaction thermodynamics in dehydrogenases. |
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