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Increased frequency of 6-thioguanine-resistant peripheral blood lymphocytes in Werner syndrome patients |
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| Authors: | Ken-ichiro Fukuchi Kiyoji Tanaka Yuichi Kumahara Kazuo Marumo Matthew B. Pride George M. Martin Raymond J. Monnat Jr. |
| Affiliation: | (1) Department of Medicine and Geriatrics, Osaka University Medical School, Fukushima-ku, 553 Osaka, Japan;(2) Department of Pathology SM-30, University of Washington, 98195 Seattle, WA, USA;(3) Institute for Cellular and Molecular Biology, Osaka University, Yamada-oka, Suita, 565 Osaka, Japan;(4) The Second Department of Internal Medicine, Osaka City University Medical School, Abeno-ku, 545 Osaka, Japan |
| Abstract: | Summary The frequency of spontaneous 6-thioguanine (TG)-resistant peripheral blood lymphocytes in five unrelated Werner syndrome (WS) patients was determined using an autoradiographic labeling assay. The average frequency of TG-resistant lymphocytes was eightfold higher in WS patients than in sex- and age-matched normal control donors. This finding and previous identification of increased spontaneous chromosomal rearrangements and deletions in WS cells or cell lines suggest that WS is a human genomic instability or mutator syndrome. |
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