Gonadotropin regulation of rat ovarian lysosomes: Existence of a hormone specific dual control mechanism |
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| Authors: | N Dhanasekaran N R Moudgal |
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| Institution: | (1) Department of Biochemistry, Indian Institute of Science, 560 012 Bangalore, PIN, India;(2) Department of Pharmacology, University of Wisconsin Medical School, 1300 University Avenue, 53706 Madison, WI, USA |
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| Abstract: | Gonadotropic hormones PMSG (15 IU/rat), FSH (3  g/rat), LH (9 g/rat) and hCG (3 g/rat) were shown to decrease the free cytosolic lysosomal enzymes during the acute phase of hormone action in rat ovaries. When isolated cells from such rats were analyzed for the cathepsin-D activity, the granulosa cells of the ovary showed a reduction in the free as well as in the total lysosomal enzyme activities in response to FSH/PMSG; the stromal and thecal compartment of the ovary showed a reduction only in the free activity in response to hCG/PMSG. The results suggest the presence of two distinct, target cell specific, mechanisms by which the lysosmal activity of the ovary is regulated by gonadotropins.Abbreviations PMSG
pregnant mare serum gonadotropin
- FSH
follicle stimulating hormone
- LH
luteinizing hormone
- hCG
human chorionic gonadotropin
- GC
granulosa cells
- S/T
stromal and thecal cells |
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| Keywords: | gonadotropins PMSG FSH LH hCG lysosomes cathepsin-D |
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