Methylenebissantin: a rare methylene-bridged bisflavonoid from Dodonaea viscosa which inhibits Plasmodium falciparum enoyl-ACP reductase |
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| Authors: | Muhammad Akhtar Anis Itrat Ali Zulfiqar Awadelkarim Sufyan Khan Ajmal Khalid Asaad Shah Muhammad Raza Galal M Khan Ikhlas A Iqbal Choudhary M |
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| Affiliation: | Department of Chemistry, University of Karachi, Karachi 75270, Pakistan. |
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| Abstract: | A new methylene-bridged bisflavonoid, methylenebissantin (1), and nine known compounds, including flavonoids (2-5), diterpenoids (6 and 7), and phenol derivatives (8-10) were isolated from the aerial parts of Dodonaea viscosa Jacq. The structure elucidation was based on spectroscopic data analyses. The isolated compounds were evaluated for the inhibition of Plasmodium falciparum enoyl-ACP reductase (PfENR). Methylenebissantin (1) exhibited a moderate inhibition (IC(50) 91.13 μM) against PfENR. |
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