首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Effect of furosemide on pulmonary blood flow distribution in resting and exercising horses.
Authors:H H Erickson  S L Bernard  R W Glenny  M R Fedde  N L Polissar  R J Basaraba  S M Walther  E M Gaughan  R McMurphy  M P Hlastala
Institution:Department of Anatomy and Physiology, Kansas State University, Manhattan, Kansas 66506-5602, USA. erickson@vet.ksu.edu
Abstract:We determined the spatial distribution of pulmonary blood flow (PBF) with 15-micron fluorescent-labeled microspheres during rest and exercise in five Thoroughbred horses before and 4 h after furosemide administration (0.5 mg/kg iv). The primary finding of this study was that PBF redistribution occurred from rest to exercise, both with and without furosemide. However, there was less blood flow to the dorsal portion of the lung during exercise postfurosemide compared with prefurosemide. Furosemide did alter the resting perfusion distribution by increasing the flow to the ventral regions of the lung; however, that increase in flow was abated with exercise. Other findings included 1) unchanged gas exchange and cardiac output during rest and exercise after vs. before furosemide, 2) a decrease in pulmonary arterial pressure after furosemide, 3) an increase in the slope of the relationship of PBF vs. vertical height up the lung during exercise, both with and without furosemide, and 4) a decrease in blood flow to the dorsal region of the lung at rest after furosemide. Pulmonary perfusion variability within the lung may be a function of the anatomy of the pulmonary vessels that results in a predominantly fixed spatial pattern of flow distribution.
Keywords:
点击此处可从《Journal of applied physiology (Bethesda, Md. : 1985)》浏览原始摘要信息
点击此处可从《Journal of applied physiology (Bethesda, Md. : 1985)》下载免费的PDF全文
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号