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Steady-state increase of cAMP-response element binding protein, Rac, and PAK signaling in presenilin-deficient neurons
Authors:Barnes Natalie Y  Shi Jun  Yajima Hiroshi  Thinakaran Gopal  Parent Angèle T
Institution:Department of Neurobiology, University of Chicago, Chicago, Illinois, USA;
Department of Neurology, University of Chicago, Chicago, Illinois, USA
Abstract:Mutations in the genes encoding presenilins (PS1 and PS2) account for the majority of cases of early-onset Alzheimer's disease. PS1 and PS2 form the catalytic center of γ-secretase, an enzyme responsible for intramembraneous proteolysis of several type I transmembrane proteins. Many γ-secretase substrates are coupled to intracellular signaling events such as cAMP-response element binding protein and Rac1/p21-activated kinase pathways, which are associated with synaptic function. Here, we have examined the activation of these pathways in neurons lacking PS1 expression or γ-secretase activity. We found evidence for heightened steady-state activation of cAMP-response element binding protein, Rac1, and p21-activated kinase signaling in PS-deficient neurons. Our study highlights the importance of PS-dependent proteolytic cleavage of γ-secretase substrates in regulating neuronal signal transduction.
Keywords:Alzheimer's disease  cyclic AMP  GTPase  p21-activated kinase  phosphorylation  γ-secretase
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