Desynchronizing double-pulse phase resetting and application to deep brain stimulation |
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Authors: | Peter A Tass |
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Institution: | (1) Institute of Medicine, Research Centre Jülich, 52425 Jülich, Germany, DE |
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Abstract: | Based on a stochastic phase-resetting approach, three different double-pulse stimulation techniques are presented here which
make it possible to effectively desynchronize a population of phase oscillators in the presence of noise. In the three sorts
of double pulses the first, stronger pulse restarts the cluster independent of its initial dynamic state. The three methods
differ with respect to the mechanism through which the second, weaker pulse desynchronizes the cluster. Both first and second
pulses are delivered to the same site. Because of the oscillators' global couplings in the model under consideration, the
incoherent state is unstable, so that after the desynchronization the cluster tends to resynchronize. However, resynchronization
is effectively blocked by repeated administration of a double pulse. The experimental application of double-pulse stimulation
is explained in detail. In particular, demand-controlled deep brain double-pulse stimulation is suggested for the therapy
of patients suffering from Parkinson's disease or essential tremor.
Received: 22 November 2000 / Accepted in revised form: 26 April 2001 |
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Keywords: | |
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