Influence of prostaglandin F autoantibodies on the estrous cycle of the guinea pig |
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Authors: | Helga E Hildebrandt-Stark George J Marcus Koji Yoshinaga Harold R Behrman Roy O Greep |
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Institution: | Laboratory of Human Reproduction and Reproductive Biology Department of Anatomy, Harvard Medical School Boston, Massachusetts 02115 USA |
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Abstract: | Adult female guinea pigs were actively immunized with prostaglandin F2α conjugated to bovine serum albumin (BSA). Control animals, immunized against BSA continued to cycle normally, while the animals immunized against prostaglandin F2α stopped cycling after one to three normal cycles. Laparotomy at 30 days after the last estrus revealed no recently formed corpora lutea. During the remaining 70 days of observation the antibody titer increased to 1:700, accompanied by increasing total serum estrogens (136 pg/ml at day 100) and a slow decline in circulating progesterone levels (0.6 ng/ml at day 100). The ovaries at day 100 contained degenerated corpora lutea and luteinized follicles. The suppression of the estrous cycle in the present experiments was interpreted as resulting from prolongation of luteal function as well as from inhibition of ovulation. |
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