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Quod erat demonstrandum? The mystery of experimental validation of apparently erroneous computational analyses of protein sequences
Authors:Lakshminarayan M Iyer  L Aravind  Peer Bork  Kay Hofmann  Arcady R Mushegian  Igor B Zhulin  Eugene V Koonin
Institution:1. National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, 20894, USA
2. EMBL, Biocomputing, Meyerhofstrasse 1, 69117, Heidelberg, Germany
3. MEMOREC Stoffel GmbH, K?ln, D-50829, Germany
4. Stowers Institute for Medical Research, 1000 E 50th Street, Kansas City, MO, 64410, USA
5. School of Biology, Georgia Institute of Technology, Atlanta, GA, 30332, USA
Abstract:

Background  

Computational predictions are critical for directing the experimental study of protein functions. Therefore it is paradoxical when an apparently erroneous computational prediction seems to be supported by experiment.
Keywords:
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