Anti-TNF antibody treatment reduces mortality in experimental dengue virus infection |
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Authors: | Atrasheuskaya Alena Petzelbauer Peter Fredeking Terry M Ignatyev George |
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Affiliation: | State Research Center of Virology and Biotechnology Vector, Novosibirsk region, Russia. |
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Abstract: | Here we describe a lethal mouse model infected with dengue virus type 2 with several similarities to human DEN-2 infection. Clinically animals demonstrated anemia, thrombocytopenia, pre-terminal paralysis and shock. The most impressive changes were seen with tumor necrosis factor (TNF)-alpha, which abruptly and steeply increased 24 h before the exitus (mean at day 6). Serum levels of IL-1beta, IL-6, IL-10, IL-1 receptor antagonist and soluble TNF receptor I continuously increased during the time of infection. A 100% mortality rate was noted in that group of animals. Treating animals with anti-TNF-alpha serum reduced mortality rate down to 40% (P<0.05). Our model supports the view that activation of innate immune response is at least partially responsible for mortality in DEN-2 infection, and in line with this concept, anti-TNF treatment significantly reduces mortality rates. |
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Keywords: | Dengue virus type 2 Mouse Cytokine Receptor Anti-tumor necrosis factor-α serum |
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