Model system oxidations supporting the crystal growth model of ferritin iron uptake |
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Authors: | Bruce G Goldner Ann L Rinehart Harry M Benshoff Daniel C Harris |
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Institution: | Department of Chemistry, Franklin and Marshall College, Lancaster, PA 17604 U.S.A. |
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Abstract: | Fe2+ is oxidized and taken up by ferritin or ápoferritin in the presence of dioxygen. Iodate causes Fe2+ oxidation and uptake by ferritin, but not by apoferritin. Synthetic iron polymer facilitates Fe2+ oxidation by either dioxygen or iodate. Nitrilotriacetic acid or iminodiacetic acid facilitate oxidation of Fe2+ by oxygen but not by iodate. These results support the crystal growth model of ferritin iron uptake, with iron polymer serving as a model for the ferritin core and aminocarboxylic acids mimicking the metal-binding sites of apoferritin. |
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Keywords: | Ferritin Iron uptake Oxidation Crystal growth model |
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