Relation of CuZnSOD activity with renal insufficiency in hypertensive diabetic patients |
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Authors: | Stancic Ana Rasic-Milutinovic Zorica Perunicic-Pekovic Gordana Buzadzic Biljana Korac Aleksandra Otasevic Vesna Jankovic Aleksandra Vucetic Milica Korac Bato |
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Institution: | University of Belgrade, Institute for Biological Research "Sinisa Stankovic", Department of Physiology, Serbia. |
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Abstract: | Diabetes and renal insufficiency are interrelated metabolic disorders closely associated with redox homeostasis disturbances. The aim of this study was to compare the activity of copper zinc superoxide dismutase (CuZnSOD) in the erythrocytes of hypertensive diabetic patients with or without renal insufficiency with normal healthy control subjects. In both groups of diabetic patients, blood glucose level and the content of glycosylated hemoglobin (HbA1c) were higher than in the control group. However, CuZnSOD activity was significantly higher than control only in hypertensive diabetic patients with renal insufficiency. Our results suggest that disturbances in superoxide homeostasis do correlate with long-term complication in diabetes, i.e. diabetic renal insufficiency and hypertension. |
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