Inhibitors of bacterial enoyl acyl carrier protein reductase (FabI): 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4-b]indoles as potential antibacterial agents |
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| Authors: | Seefeld M A Miller W H Newlander K A Burgess W J Payne D J Rittenhouse S F Moore T D DeWolf W E Keller P M Qiu X Janson C A Vaidya K Fosberry A P Smyth M G Jaworski D D Slater-Radosti C Huffman W F |
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| Institution: | GlaxoSmithKline Pharmaceuticals, Antimicrobial and Host Defense Division, 1250 S. Collegeville Road, Collegeville, PA 19426, USA. mark_a_seefeld@sbphrd.com |
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| Abstract: | An SAR study of a screening lead has led to the identification of 2,9-disubstituted 1,2,3,4-tetrahydropyrido3,4-b]indoles as inhibitors of Staphylococcus aureus enoyl acyl carrier protein reductase (FabI). |
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