4-Amino-6-piperazin-1-yl-pyrimidine-5-carbaldehyde oximes as potent FLT-3 inhibitors |
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| Authors: | Gaul Micheal D Xu Guozhang Kirkpatrick Jennifer Ott Heidi Baumann Christian A |
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| Affiliation: | Johnson and Johnson Pharmaceutical Research and Development LLC, Cranbury, NJ 08512, USA. mgaul@prdus.jnj.com |
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| Abstract: | A series of 4-amino-6-piperazin-1-yl-pyrimidine-5-carbaldehyde oximes has been discovered and developed as potent FLT3 tyrosine kinase inhibitors. The series exhibited potent antiproliferative activity against both an FLT3 ITD-mutated human leukemic cell line as well as a wild-type FLT3 BaF(3) expressed cell line. The structure-activity relationship of this class of compounds is described. |
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