Modular evolution of glutathione peroxidase genes in association with different biochemical properties of their encoded proteins in invertebrate animals |
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| Authors: | Young-An Bae Guo-Bin Cai Seon-Hee Kim Young-Gun Zo and Yoon Kong |
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| Institution: | (1) Department of Molecular Parasitology, Sungkyunkwan University School of Medicine and Center for Molecular Medicine, Samsung Biomedical Research Institute, Suwon, Gyeonggi-do, 440-746, Korea;(2) Department of Parasitology, School of Medicine, Wuhan University, Wuhan, PR, China;(3) Department of Environmental Science, Kangwon National University, Chuncheon, Korea |
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| Abstract: | Background Phospholipid hydroperoxide glutathione peroxidases (PHGPx), the most abundant isoforms of GPx families, interfere directly
with hydroperoxidation of lipids. Biochemical properties of these proteins vary along with their donor organisms, which has
complicated the phylogenetic classification of diverse PHGPx-like proteins. Despite efforts for comprehensive analyses, the
evolutionary aspects of GPx genes in invertebrates remain largely unknown. |
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