Localization of CD26/DPPIV in nucleus and its nuclear translocation enhanced by anti-CD26 monoclonal antibody with anti-tumor effect |
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| Authors: | Kohji Yamada Mutsumi Hayashi Wenlin Du Kei Ohnuma Michiie Sakamoto Chikao Morimoto Taketo Yamada |
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| Institution: | (1) Department of Pathology, Keio University School of Medicine, Tokyo, Japan;(2) Division of Clinical Immunology, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan |
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| Abstract: | Background CD26 is a type II, cell surface glycoprotein known as dipeptidyl peptidase (DPP) IV. Previous studies have revealed CD26 expression
in T cell leukemia/lymphoma and malignant mesothelioma, and an inhibitory effect of anti-CD26 monoclonal antibody (mAb) against
the growth of CD26+ cancer cells in vitro and in vivo. The function of CD26 in tumor development is unknown and the machinery
with which the CD26 mAb induces its anti-tumor effect remains uncharacterized. |
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