The Potential Role of Nitric Oxide Synthase in Survival and Regeneration of Magnocellular Neurons of Hypothalamo-Neurohypophyseal System |
| |
Authors: | Qiuju Yuan David E Scott Kwow-Fai So Zhixiu Lin Wutian Wu |
| |
Institution: | (1) Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China;(2) State Key Laboratory of Brain and Cognitive Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China;(3) Research Center of Reproduction, Development and Growth, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China;(4) School of Chinese Medicine, Faculty of Science, The Chinese University of Hong Kong, Shatin, N.T, Hong Kong SAR, China;(5) The Department of Pathology & Anatomy, The Eastern Virginia Medical School, Norfolk, VA, USA |
| |
Abstract: | Previous investigations from this laboratory have demonstrated that hypophysectomy induces up-regulation of neuronal nitric
oxide synthase (nNOS) in magnocellular neurons of the mammalian hypothalamo-neurohypophyseal system (HNS). Accompanied by
this upregulation of nNOS, both neuronal regeneration and degeneration are also observed in this system following hypophysectomy.
The specific aim of this study was to determine the potential role of nNOS upregulation in neuronal survival and regeneration
after hypophysectomy in the adult Sprague–Dawley (SD) rat by using a competitive nitric oxide synthase blocker, N(G)-nitrol-l-arginine methyl ester (l-NAME). We found that l-NAME treatment effectively blocked the regeneration of magnocellular neurons of the rodent hypothalamus as observed in the
lumen of the third cerebral ventricle following hypophysectomy. However, l-NAME had no effect on the survival of magnocellular neurons in the supraoptic (SON) and paraventricular (PVN) nuclei after
hypophysectomy. These results suggest that the induced increase of nNOS expression enhance the regenerative ability of magnocellular
neurons of the HNS following hypophysectomy. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|