A naturally occurring novel allele of Escherichia coli outer membrane protein A reduces sensitivity to bacteriophage |
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| Authors: | Power Michelle L Ferrari Belinda C Littlefield-Wyer Jane Gordon David M Slade Martin B Veal Duncan A |
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| Institution: | Department of Biological Sciences, Macquarie University, North Ryde, Sydney, NSW 2109, Australia. mpower@els.mq.edu.au |
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| Abstract: | A novel Escherichia coli outer membrane protein A (OmpA) was discovered through a proteomic investigation of cell surface proteins. DNA polymorphisms were localized to regions encoding the protein's surface-exposed loops which are known phage receptor sites. Bacteriophage sensitivity testing indicated an association between bacteriophage resistance and isolates having the novel ompA allele. |
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