Spike initiation and propagation on axons with slow inward currents |
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Authors: | Thomas B. Kepler Eve Marder |
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Affiliation: | (1) Department of Biology and Center for Complex Systems, Brandeis University, 02254 Waltham, MA, USA;(2) Present address: Biomathematics Department, North Carolina State University, Campus Box 8203, 27695 Raleigh, NC, USA |
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Abstract: | We investigate spike initiation and propagation in a model axon that has a slow regenerative conductance as well as the usual Hodgkin-Huxley type sodium and potassium conductances. We study the role of slow conductance in producing repetitive firing, compute the dispersion relation for an axon with an additional slow conductance, and show that under appropriate conditions such an axon can produce a traveling zone of secondary spike initiation. This study illustrates some of the complex dynamics shown by excitable membranes with fast and slow conductances. |
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