Habitual sleep and human plasma metabolomics |
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Authors: | Qian Xiao Andriy Derkach Steven C. Moore Wei Zheng Xiao-Ou Shu Fangyi Gu Neil E. Caporaso Joshua N. Sampson Charles E. Matthews |
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Affiliation: | 1.Department of Health and Human Physiology,University of Iowa,Iowa City,USA;2.Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute,National Institutes of Health,Rockville,USA;3.Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute,National Institutes of Health,Rockville,USA;4.Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, and Vanderbilt-Ingram Cancer Center,Vanderbilt University School of Medicine,Nashville,USA;5.Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute,National Institutes of Health,Rockville,USA |
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Abstract: | IntroductionSleep plays an important role in cardiometabolic health. The sleep-wake cycle is partially driven by the endogenous circadian clock, which governs a range of metabolic pathways. The association between sleep and cardiometabolic health may be mediated by alterations of the human metabolome.ObjectivesTo better understand the biological mechanism underlying the association between sleep and health, we examined human plasma metabolites in relation to sleep duration and sleep timing.MethodsUsing an untargeted approach, 329 fasting plasma metabolites were measured in 277 Chinese participants. We measured sleep timing (midpoint between bedtime and wake up time) using repeated time-use surveys (4 weeks during 1 year) and previous night sleep duration from questionnaires completed before sample donation.ResultsWe found 64 metabolites that were associated with sleep timing with a false discovery rate of 0.2 or lower, after adjusting for potential confounders. Notably, we found that later sleep timing was associated with higher levels of multiple metabolites in amino acid metabolism, including branched chain amino acids and their gamma-glutamyl dipeptides. We also found widespread associations between sleep timing and numerous metabolites in lipid metabolism, including bile acids, carnitines and fatty acids. In contrast, previous night sleep duration was not associated with plasma metabolites in our study.ConclusionSleep timing was associated with a large number of metabolites across a variety of biochemical pathways. Some metabolite associations are consistent with a relationship between late chronotype and adverse effects on cardiometabolic health. |
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