Systemic effects of chronically administered methyl prednisolonate and methyl 17-deoxyprednisolonate |
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| Authors: | E Olejniczak H J Lee |
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| Affiliation: | Center for Anti-inflammatory Research College of Pharmacy, Florida A&M University Tallahassee, Florida 32307 USA |
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| Abstract: | The systemic activities of methyl prednisolonate and methyl 17-deoxyprednisolonate (1) were studied in rats. Methyl 17-deoxyprednisolonate produced significant changes in the amount of sodium ion (decreased) and potassium ion (increased) in urine; however, methyl prednisolonate had no effect on electrolyte balance. Both methyl prednisolonate and methyl 17-deoxyprednisolonate had no effect on liver glycogen content, plasma corticosterone level and relative adrenal weight. In contrast, the parent compound prednisolone caused a significant decrease in liver glycogen content, plasma corticosterone level and relative adrenal weight. |
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| Keywords: | Steroid nomenclature: prednisolone (11β17,21-trihydroxy-1, 4-pregnadiene-3,20-dione) methyl prednisolonate (methyl 11β, 17-dihydroxy-3,20-dioxo-1,4-pregnadien-21-oate) methyl 17-deoxyprednisolonate (methyl 11β-hydroxy-3,20-dioxo-1,4-pregnadien-21-oate) 11-deoxycorticosterone (21-hydroxy-4-pregnene-3,20-dione) budesonide (16,17-butylidenebis(oxy)-11,21-dihydroxypregna-1,4-diene-3,20-dione) |
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