Binding study of the drug cis-dichlorodiammineplatinum(II)to G p5′ and dGp5′ by high resolution proton and carbon-13 NMR spectroscopy |
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| Authors: | Moschos Polissiou Minh Tan Phan Viet Maurice St-Jacques Theophile Theophanides |
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| Institution: | Université de Montréal, Department of Chemistry, Montréal, Que., H3C 3V1, Canada |
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| Abstract: | The molecular mode of action leading to the anticancer activity of the drug cis-diamminedichloroplatinum(II), cis-DDP or cis-platinum is still the subject of speculation. In the present high field (400 MHz) 1H NMR study the results on coupling constants for cis- and trans-diammine bis(guanosine- 5′-monophosphate) and (d-guanosine-5′-monophosphate)platinum(II) complexes are presented and discussed. The 1H and 13C NMR chemical shifts obtained are consistent with the drug binding to N7 of each guanine. It has been found that the drug induces different conformational changes in the nucleotide from the trans-DDP isomer. |
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| Keywords: | Author to whom correspondence should be addressed |
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