Microcalorimetric evaluation of the biological activity of polyene complexes with divalent metal ions: Mg(II), Ca(II), Ni(II), Cu(II) and Zn(II) |
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| Authors: | Anthony E Beezer Paul O&#x;Brien Roger J Miles Won-Bong Park Wai L Sham |
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| Institution: | Chemistry Department, Royal Holloway and Bedford Colleges, University of London, Egham, Surrey, TW20 0EX, U.K. |
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| Abstract: | Polyene complexes with Mg(II), Ca(II), Ni(II), Cu(II) and Zn(II) have been prepared and evaluated for biological activity in a flow microcalorimetric study. The bioactivities are all lower per g of complex than is the bioactivity of the patent polyene, nystatin. However extrapolation of the linear bioassay data suggests that because of enhanced solubilities the metal ion complexes may be able to yield higher overall bioactivity than can nystatin alone. |
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| Keywords: | Author to whom correspondence should be addressed |
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