| 基因工程功能化丝蛋白生物材料及其在生物医学中的应用 |
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| 引用本文： | 张蕾,向仲怀,赵盖超,吴宗辉,崔红娟. 基因工程功能化丝蛋白生物材料及其在生物医学中的应用[J]. 生物工程学报, 2019, 35(6): 956-971 |
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| 作者姓名： | 张蕾 向仲怀 赵盖超 吴宗辉 崔红娟 |
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| 作者单位： | 1 西南大学 家蚕基因组生物学国家重点实验室，重庆 400716;2 重庆市蚕丝生物材料与再生医学工程研究中心，重庆 400716;3 西南大学 肿瘤生物医学与转化工程研究中心，重庆 400716,1 西南大学 家蚕基因组生物学国家重点实验室，重庆 400716;2 重庆市蚕丝生物材料与再生医学工程研究中心，重庆 400716;3 西南大学 肿瘤生物医学与转化工程研究中心，重庆 400716,1 西南大学 家蚕基因组生物学国家重点实验室，重庆 400716;2 重庆市蚕丝生物材料与再生医学工程研究中心，重庆 400716;3 西南大学 肿瘤生物医学与转化工程研究中心，重庆 400716,4 西南大学 西南大学医院，重庆 400716,1 西南大学 家蚕基因组生物学国家重点实验室，重庆 400716;2 重庆市蚕丝生物材料与再生医学工程研究中心，重庆 400716;3 西南大学 肿瘤生物医学与转化工程研究中心，重庆 400716 |
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| 基金项目： | 中央高校基本科研业务费 (No. XDJK2018C010) 资助。 |
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| 摘 要： | 丝蛋白生物材料具有优异的力学性能、良好的生物相容性及可降解性,在生物医学领域具有巨大的应用潜力。现有丝蛋白生物材料在结构和功能方面的相关知识,为设计合成新型丝蛋白生物材料提供了理论基础。此外,利用基因工程技术可将编码新肽或结构域的基因序列添加到编码丝蛋白的基因序列中,以获得具有新功能的丝蛋白生物材料,并更好地满足现代生物医学的需求。文中总结了基因工程功能化的丝蛋白生物材料在生物医学领域中的应用现状和发展前景。
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| 关 键 词： | 丝蛋白，生物材料，功能化，基因工程，生物医学 |
| 收稿时间： | 2018-10-23 |
Functionalized genetic engineered silk-based biomaterials and their applications |
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| Lei Zhang,Zhonghuai Xiang,Gaichao Zhao,Zonghui Wu and Hongjuan Cui. Functionalized genetic engineered silk-based biomaterials and their applications[J]. Chinese journal of biotechnology, 2019, 35(6): 956-971 |
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| Authors: | Lei Zhang Zhonghuai Xiang Gaichao Zhao Zonghui Wu Hongjuan Cui |
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| Affiliation: | 1 State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, China;2 Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Chongqing 400716, China;3 Engineering Research Center for Cancer Biomedical and Translational Medicine, Southwest University, Chongqing 400716, China,1 State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, China;2 Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Chongqing 400716, China;3 Engineering Research Center for Cancer Biomedical and Translational Medicine, Southwest University, Chongqing 400716, China,1 State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, China;2 Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Chongqing 400716, China;3 Engineering Research Center for Cancer Biomedical and Translational Medicine, Southwest University, Chongqing 400716, China,4 Hospital of Southwest University, Southwest University, Chongqing 400716, China and 1 State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, China;2 Chongqing Engineering and Technology Research Center for Silk Biomaterials and Regenerative Medicine, Chongqing 400716, China;3 Engineering Research Center for Cancer Biomedical and Translational Medicine, Southwest University, Chongqing 400716, China |
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| Abstract: | Silk-based biomaterials are featured with excellent mechanical properties, good biocompatibility and biodegradability, which contribute to their potential applications in biomedical field. The current recognition of silk protein materials in structure and function provides a basic theory for the transformation of silk protein into new types of biomaterials. In addition, exogenous sequences encoding new peptide or structural domain can be inserted into the maternal gene sequences encoding silk proteins through genetic engineering technology to synthesize novel silk-based biomaterials with unique functions. This review summarizes the current trend and development perspective of genetically engineered functional silk-based materials for biomedical applications. |
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| Keywords: | silk protein biomaterials functionalization genetic engineering biomedicine |
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