| 紧密连接蛋白claudins应用于肿瘤治疗的进展 |
| |
| 引用本文： | 陈思远,刘雪,罗文新. 紧密连接蛋白claudins应用于肿瘤治疗的进展[J]. 生物工程学报, 2019, 35(6): 931-941 |
| |
| 作者姓名： | 陈思远 刘雪 罗文新 |
| |
| 作者单位： | 厦门大学 生命科学学院 公共卫生学院 国家传染病诊断试剂与疫苗工程技术研究中心 分子疫苗学和分子诊断学国家重点实验室，福建 厦门 361102,厦门大学 生命科学学院 公共卫生学院 国家传染病诊断试剂与疫苗工程技术研究中心 分子疫苗学和分子诊断学国家重点实验室，福建 厦门 361102,厦门大学 生命科学学院 公共卫生学院 国家传染病诊断试剂与疫苗工程技术研究中心 分子疫苗学和分子诊断学国家重点实验室，福建 厦门 361102 |
| |
| 基金项目： | 国家自然科学基金 (No. 31870925)，传染病重大专项 (No. 2017ZX10202203-001) 资助。 |
| |
| 摘 要： | Claudins蛋白家族是组成紧密连接(Tight junctions,TJs)必不可少的骨架蛋白,在维持上皮和内皮细胞中的细胞极性、细胞间的粘附固定、细胞旁路的离子运输等发挥重要作用。近年来大量的研究结果证明,claudins在许多人类恶性肿瘤中异常表达。因此,claudins也被作为癌症治疗的潜在靶标。文中就claudin蛋白家族在肿瘤中的表达情况及其相关药物的研究进展进行阐述。
|
| 关 键 词： | claudin，肿瘤，梭菌肠毒素，抗体，靶向治疗 |
| 收稿时间： | 2018-10-25 |
Advances in the application of claudins to tumor therapy |
| |
| Siyuan Chen,Xue Liu and Wenxin Luo. Advances in the application of claudins to tumor therapy[J]. Chinese journal of biotechnology, 2019, 35(6): 931-941 |
| |
| Authors: | Siyuan Chen Xue Liu Wenxin Luo |
| |
| Affiliation: | State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, School of Life Sciences, Xiamen University, Xiamen 361102, Fujian, China,State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, School of Life Sciences, Xiamen University, Xiamen 361102, Fujian, China and State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, School of Life Sciences, Xiamen University, Xiamen 361102, Fujian, China |
| |
| Abstract: | Claudin proteins are the most crucial components of tight junctions, and play an essential role in maintaining cell polarity, regulating cell permeability and the intercellular ion. In recent years, many studies have shown that abnormality of claudins expression is implicated in the tumor progression. The expression correlates with tumor prognosis and can serve as a biomarker of prognosis and potential therapeutic targets. This review summarizes the current knowledge regarding claudin dysregulation in cancer and highlights the progress in claudin-based treatments. |
| |
| Keywords: | claudin tumor Clostridium perfringens enterotoxin antibody targeted therapy |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《生物工程学报》浏览原始摘要信息 |
|
点击此处可从《生物工程学报》下载全文 |
|
