小花清风藤叶的化学成分研究

对于小花清风藤的化学成分和药理作用的研究目前较少报道,为了阐明小花清风藤的物质基础,该研究对小花清风藤(Sabia parviflora)的干燥叶,采用反复硅胶柱色谱、Sephadex LH-20柱色谱、制备薄层色谱及重结晶等手段进行分离纯化,运用化学分析和波谱学方法鉴定化合物的结构。结果表明:从小花清风藤干燥叶的甲醇超声提取物中进行分离共得到12个化合物,分别为N-反式阿魏酰酪胺(1)、N-顺式阿魏酰酪胺(2)、N-反式-对-香豆酰酪胺(3)、N-顺式-对-香豆酰酪胺(4)、N-反式-对-香豆酰章鱼胺(5)、N-顺式-对-香豆酰章鱼胺(6)、阿魏酸(7)、芹菜素(8)、木犀草素(9)、咖啡酸(10)、5-氧阿朴菲碱(11)、齐墩果酸(12)。其中,化合物2、4-9为首次从清风藤属植物中分离得到,化合物1、3、10为首次从该植物中分离得到。

Chemical constituents from leaves of Sabia parviflora

In order to elucidate the material basis of S. parviflora, the constituents of S. parviflora were separated and purified with chromatographic methods and recrystallization. The structures were elucidated by chemical analyses and spectroscopic methods. Twelve compounds were isolated from the leaves of S. parviflora, and they were identified as N-trans-feruloyl tyramine(1), N-cis-feruloyl tyramine(2), N-trans-p-coumaroyl tyramine(3), N-cis-p-coumaroyl tyramine(4), N-trans-p-coumaroyl octopamine(5), N-cis-p-coumaroyl octopamine(6), ferulic acid(7), apigenin(8), luteolin(9), caffeic acid(10), fuseine(11), oleanolic acid(12). Compounds 2, 4-9 were isolated from the plants of Sabia Colelbr. for the first time. Compounds 1, 3, 10 were isolated from the plant for the first time.