| 高动态光学血管造影成像 |
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| 引用本文： | 曾亚光,罗佳雄,韩定安,熊红莲,王雪花,钟俊平,王茗祎. 高动态光学血管造影成像[J]. 生物化学与生物物理进展, 2019, 46(6): 612-619 |
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| 作者姓名： | 曾亚光 罗佳雄 韩定安 熊红莲 王雪花 钟俊平 王茗祎 |
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| 作者单位： | 佛山科学技术学院物理与光电工程学院，佛山 528000,佛山科学技术学院物理与光电工程学院，佛山 528000,佛山科学技术学院物理与光电工程学院，佛山 528000,佛山科学技术学院物理与光电工程学院，佛山 528000,佛山科学技术学院物理与光电工程学院，佛山 528000,佛山科学技术学院物理与光电工程学院，佛山 528000,佛山科学技术学院物理与光电工程学院，佛山 528000 |
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| 基金项目： | 国家自然科学基金(61605026，11474053，61471123，61771139，81601534，61705036)，广东省自然科学基金(2015A030313639，2017A030313386)和广东省大学学生创新创业训练项目(XJ2018039)资助. |
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| 摘 要： | 我们提出一种高动态光学血管造影成像(HDOA)方法来实现活体生物样本血管造影成像.该方法通过设置高动态范围曝光时间,依据动态积分效应和吸收效应以实现高动态积分时间调制.通过该方法,不仅能够同时获得各级血管清晰的造影图像,还能消除样品厚度不均、吸收系数不同对成像造成的影响.论文以仿体和活体金鱼为样品,通过实验验证了HDOA方法根据动态积分调制效应和吸收效应,能有效实现各级血管同时成像.
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| 关 键 词： | 高动态光学血管造影成像 高动态积分时间调制 吸收效应 |
| 收稿时间： | 2019-04-09 |
| 修稿时间： | 2019-04-29 |
High-Dynamic Optical Angiography |
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| ZENG Ya-Guang,LUO Jia-Xiong,HAN Ding-An,XIONG Hong-Lian,WANG Xue-Hu,ZHONG Jun-Ping and WANG Ming-Yi. High-Dynamic Optical Angiography[J]. Progress In Biochemistry and Biophysics, 2019, 46(6): 612-619 |
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| Authors: | ZENG Ya-Guang LUO Jia-Xiong HAN Ding-An XIONG Hong-Lian WANG Xue-Hu ZHONG Jun-Ping WANG Ming-Yi |
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| Affiliation: | School of Physics and Optoelectronic Engineering, Foshan University, Foshan 528000, China,School of Physics and Optoelectronic Engineering, Foshan University, Foshan 528000, China,School of Physics and Optoelectronic Engineering, Foshan University, Foshan 528000, China,School of Physics and Optoelectronic Engineering, Foshan University, Foshan 528000, China,School of Physics and Optoelectronic Engineering, Foshan University, Foshan 528000, China,School of Physics and Optoelectronic Engineering, Foshan University, Foshan 528000, China,School of Physics and Optoelectronic Engineering, Foshan University, Foshan 528000, China |
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| Abstract: | We propose a high-dynamic optical angiography(HDOA) method to obtain blood flow images of a small biological specimen in vivo. High dynamic range exposure time is set to achieve high-dynamic integrated time modulation, which involves dynamic integrated effect and absorption effect. With this method, each-level vessels can be imaged with similar clarity. Moreover, the vessels in locations with different thickness and absorption coefficient can be reconstructed in the same image. Experiments on phantom and in vivo Gold Pristella Tetra were performed to demonstrate that HDOA can achieve each-level vessels imaging based on dynamic integrated effect and absorption effect. |
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| Keywords: | high-dynamic optical angiography high-dynamic integrated time modulation absorption effect |
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