Specific sensing of poly G by the aluminum-salophen complex |
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Authors: | Cametti Massimo Piantanida Ivo Zinić Mladen Dalla Cort Antonella Mandolini Luigi Marjanović Marko Kralj Marijeta |
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Institution: | Dipartimento di Chimica and IMC-CNR, Università La Sapienza, Box 34, Roma 62, Italy. |
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Abstract: | The Al(III)-salophen complex 1 exhibited strong spectroscopic changes specifically upon addition of polyG and GpG, while double stranded DNA and RNA, and single stranded polyA, polyU and polyC induced negligible spectral changes of 1. Titrations with mono-nucleotides yielded no spectroscopic changes, revealing that there must be at least two consecutive guanines in single stranded oligonucleotide structure for a measurable spectroscopic change of 1. Preliminary results show that 1 has moderate antiproliferative effect on a number of human tumour cell lines. |
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Keywords: | Salophen-metal complex DNA RNA Aluminum |
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