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3-amido-4-anilinocinnolines as a novel class of CSF-1R inhibitor |
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| Authors: | Scott David A Dakin Les A Del Valle David J Diebold R Bruce Drew Lisa Gero Thomas W Ogoe Claude A Omer Charles A Repik Galina Thakur Kumar Ye Qing Zheng Xiaolan |
| Affiliation: | Cancer Research, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA |
| Abstract: | 3-Amido-4-anilinocinnolines have been identified as potent and highly selective inhibitors of CSF-1R. The synthesis and SAR of these compounds is reported, along with some physical property, pharmacokinetic and kinase selectivity data. |
| Keywords: | Kinase inhibitor Cinnoline CSF-1R |
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