Characterization of the free radical formed in aerobic microsomal incubations containing carbon tetrachloride and NADPH. |
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| Authors: | B Kalyanaraman R P Mason E Perez-Reyes C F Chignell C R Wolf R M Philpot |
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| Institution: | Laboratory of Environmental Biophysics National Institute of Environmental Health Sciences Post Office Box 12233 Research Triangle Park, North Carolina 27709 USA;Laboratory of Pharmacology National Institute of Environmental Health Sciences Post Office Box 12233 Research Triangle Park, North Carolina 27709 USA |
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| Abstract: | Aerobic microsomal incubations containing either lipoxygenase or carbon tetrachloride and NADPH apparently produce the same free radical, as determined by spin trapping. The spectrum of the radical trapped in the presence of CCl4 and NADPH is consistent with a carbon-centered dienyl lipid radical adduct. This species had previously been identified as the trichloromethyl radical adduct. |
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| Keywords: | ESR electron spin resonance PBN MNP 2-methyl-2-nitrosopropane |
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