Signaling inputs converge on nuclear effectors in TGF-beta signaling |
| |
Authors: | ten Dijke P Miyazono K Heldin C H |
| |
Institution: | Ludwig Institute for Cancer Research, Box 595, S-751 24 Uppsala, Sweden. ptdijke@nki.nl |
| |
Abstract: | Recent studies have consolidated the pivotal role of Smads as intracellular effectors of TGF-beta family members. Upon binding to their specific type I and type II serine/threonine kinase receptors, each family member activates a particular subset of Smad proteins. Activated, receptor-regulated Smads form hetero-oligomeric complexes with common-partner Smads that translocate into the nucleus, where they control the expression of target genes in a cell-type-specific manner. Smads appear to function not only as nuclear effectors for TGF-beta family members, but as signal integrators within an extensive intracellular network. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|